NUTRITION

PROTEIN CHEMISTRY

NATURAL PRODUCTS

DRUG DISCOVERY


Before pivoting into health/life science tech, I spent over a decade in academia with rigorous research projects and complex teaching programs. Please reach out for a formal research or teaching statement, and thank you for your interest in academic efforts.




PUBLISHED RESEARCH

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Clinical study

(2019)

Gut microbiome activity contributes to individual variation in glycemic response in adults. bioRxiv.

Glycemic response Clinical study Metatranscriptomics Nutrition
Personalized medicine

FDA approved NMEs

(2016)

An analysis of FDA-approved drugs: natural products and their derivatives. Drug Discovery Today.

New molecular entities Bacteria Fungi Plants Animals Natural products Semisynthetic derivatives

Fungal bioactive molecule

(2015)

Pyrrolocin A, a 3-Decalinoyltetramic Acid with Selective Biological Activity, Isolated from Amazonian Cultures of the Novel Endophyte Diaporthales sp. E6927Es. Natural Product Communications.

Pyrrolocin A Bioguided fractionation
Anti-infective agent

Research origins of NMEs

(2015)

An analysis of original research contributions toward FDA-approved drugs. Drug Discovery Today.

New molecular entities Research origins City/Country Academia Industry Biotech

Top ten targets for NMEs

(2015)

Target selection for FDA-approved medicines. Drug Discovery Today.

New molecular entities Top target classes Top drug mechanisms

Available psychiatric NMEs

(2015)

An Analysis of FDA-approved Drugs for Psychiatric Disorders. Drug Discovery Today.

New molecular entities
Psychiatric disorders Psychiatric agents

Available HIV NMEs

(2014)

An analysis of FDA-approved drugs for infectious disease: HIV/AIDS drugs. Drug Discovery Today.

New molecular entities Antiretrovirals HIV/AIDS agents

Available HIV NMEs

(2014)

An analysis of FDA-approved drugs for infectious disease: antibacterial agents. Drug Discovery Today.

New molecular entities
Infectious diseases Antibacterial agents

GST protection from alkylators

(2014)

Influence of glutathione and glutathione S-transferases on DNA interstrand cross-link formation by 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine, the active anticancer moiety generated by laromustine. Chemical Research in Toxicology.

DNA alkylation Glutathione S-Transferase Therapeutic window Anti-cancer agent

LGBQ STEM Faculty

(2014)

Factors impacting the academic climate for LGBQ STEM faculty. Journal of Women and Minorities in Science and Engineering.

LGBQ STEM Faculty Identity Comfort Outness Academic climate

Laromustine anti-cancer agent

(2013)

Chloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cells. Bioorganic & Medicinal Chemistry Letters.

Prodrug alklator DNA alkylation
Survival studies Anti-cancer compound

Hypoxia-Activated anti-cancer drugs

(2012)

4-Nitrobenzyloxycarbonyl derivatives of O6-benzylguanine as hypoxia-activated prodrug inhibitors of O6-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the O-6 position of DNA guanine. Journal of Medicinal Chemistry.

Prodrug inhibitor Therapeutic window DNA alkylation Survival studies
Anti-cancer compound

Nitrobenzofurazan superoxide generator

(2012)

7-Nitro-4-(phenylthio)benzofurazan is a potent generator of superoxide and hydrogen peroxide. Archives of toxicology.

Nitrobenzofurazan Sulfobenzofurazan ROS redox-cycling electrochemistry
anti-cancer compounds

Dissertation on WrbA

(2009)

Re-evaluating and delineating a protein family: Biochemical and biophysical investigations of WrbA, founding member of a NAD (P) H: Quinone Oxidoreductase family. PhD Dissertation, Pennsylvania State University.

Quinone reductase Electron transfer Enzymology Thermostability Electrochemistry Bioinformatics

WrbA use in biosensors

(2009)

Tryptophan repressor-binding proteins from Escherichia coli and Archaeoglobus fulgidus as new catalysts for 1,4-dihydronicotinamide adenine dinucleotide-dependent amperometric biosensors and biofuel cells. Analytical Chemistry.

WrbA protein Electron transfer Catalysis Electrochemistry

Dissertation on WrbA

(2007)

Crystal Structure of the NADH:Quinone Oxidoreductase WrbA from Escherichia coli. Journal of Bacteriology.

WrbA protein Flavoprotein Flavodoxin Crystallization Active site design
Protein modeling

WrbA as an NADPH:Quinone Oxidoreductase

(2006)

WrbA from E.coli and A.fulgidus Is an NAD(P)H:Quinone Oxidoreductase. Journal of Bacteriology.

Quinone reductase Enzyme function Bioinformatics Bacteria and Archaea Escherichia coli Archaeoglobus fulgidus





REFERENCES

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  1. Hal Tily, Ally Perlina, Eric Patridge, Stephanie Gline, Matvey Genkin, Vishakh Gopu, Haely Lindau, Alisson Sjue, Niels Klitgord, Momchilo Vuyisich, Helen Messier, Guruduth Banavar. (2019) Gut microbiome activity contributes to individual variation in glycemic response in adults. (Submitted to bioRxiv.)
  2. Patridge EV, Darnell A, Kucera K, Phillips GM, Bokesch HR, Gustafson KR, Spakowicz DJ, Zhou L, Hungerford WM, Plummer M, Hoyer D. (2015). Pyrrolocin A, a 3-Decalinoyltetramic Acid with Selective Biological Activity, Isolated from Amazonian Cultures of the Novel Endophyte Diaporthales sp. E6927E. Natural product communications. 10(10):1649-54. PMID:26669095
  3. Patridge EV, Gareiss P, Kinch MS, Hoyer D. An Analysis of Original Research Contributions toward FDA-Approved New Molecular Entities. Drug Discovery Today. 20(10):1182-7. PMID:26113307
  4. Patridge EV, Kinch MS, Gareiss P, Hoyer D. An Analysis of FDA-Approved Drugs: Natural Products and Their Derivatives. Drug Discovery Today. 21(2):204-7. PMID:25617672
  5. Kinch MS, Hoyer D, Patridge EV, Plummer M. (2014). Target Selection for FDA-Approved Medicines. Drug Discovery Today. 20(7):784-9. PMID:25462532
  6. Kinch MS, Patridge EV. (2014). An Analysis of FDA-Approved Drugs for Psychiatric Disorders. Drug Discovery Today. 20(3):292-5. PMID:25200172
  7. Kinch, MS, Patridge EV. (2014). An Analysis of FDA-approved drugs for infectious disease: HIV/AIDS drugs. Drug discovery today. 19(10):1510-3. PMID:24880109
  8. Kinch MS, Patridge EV, Plummer M, Hoyer D. (2014). An Analysis of FDA-Approved Drugs for Infectious Disease: Anti-Bacterial Agents. Drug Discovery Today. 19(9):1283-7. PMID:25043770
  9. Patridge EV, Barthelemy RS, Rankin SR. (2014). Factors Impacting the Academic Climate for LGBQ STEM Faculty. Journal of Women and Minorities in Science & Engineering. 20(1):75-98.
  10. Penketh PG, Patridge EV, Shyam K, Baumann RP, Zhu R, Ishiguro K, Sartorelli AC. (2014). Influence of glutathione and glutathione-S-transferases on DNA interstrand cross-linking formation by 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine (90CE), the active anticancer moiety generated by laromustine, KS119 and KS119W. Chemical Research in Toxicology. 27(8):1440-9. PMID:25012050
  11. Zhu R, Baumann RP, Patridge E, Penketh PG, Shyam K, Ishiguro K, Sartorelli AC. (2013). Chloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cells. Biochemical & Medicinal Chemistry Letters. 23(6):1853-9. PMID:23395657
  12. Patridge EV, Eriksson ES, Penketh PG, Baumann RP, Zhu R, Shyam K, Eriksson LA, Sartorelli AC. (2012). 7-Nitro-4-(phenylthio)benzofurazan is a potent generator of superoxide and hydrogen peroxide. Archives of Toxicology. 86(10):1613-25. PMID:22669514
  13. Penketh PG, Shyam K, Baumann RP, Ishiguro K, Patridge EV, Zhu R, Seow HA, Sartorelli AC. (2012). A strategy for selective O6-alkylguanine-DNA alkyltransferase depletion under oxygen deficient conditions. Chemical Biology & Drug Design. 80(2): 279-90. PMID:22553921
  14. Nadeem MZ, Tasca F, Gorton L, Patridge EV, Ferry JG, Nöll G. (2009). WrbA from Escherichia coli and Archaeoglobus fulgidus as New Catalyst for NADH-Dependent Amperometric Biosensors and Biofuel Cells. Analytical Chemistry. 81 (10): 4082–4088. PMID:19438267
  15. Andrade SL, Patridge EV, Ferry JG, Einsle O. (2007). Crystal Structure of NADH:Quinone Oxidoreductase WrbA from Escherichia coli. Journal of Bacteriology. 189(24): 9101-7. PMID:17951395
  16. Patridge EV, Ferry JG. (2006). WrbA from Escherichia coli and Archaeoglobus fulgidus is an NAD(P)H:Quinone Oxidoreductase. Journal of Bacteriology. 188 (10): 3498-506. PMID:16672604